Rejuran Skin Treatment

Rejuran is an injectable treatment composed of polynucleotides, which are fragments of DNA derived from salmon. These biological molecules share a high degree of compatibility with human tissue, making them exceptionally well tolerated and biocompatible. When injected superficially into the dermis, polynucleotides interact with skin cells through a process known as adenosine A2A receptor activation, triggering a cascade of regenerative responses.

This activation stimulates fibroblasts, the cells responsible for producing collagen and elastin, to increase their activity. At the same time, Rejuran promotes angiogenesis, the formation of new blood vessels, which improves nutrient delivery and oxygenation within the skin. The treatment also supports the repair and reinforcement of the extracellular matrix, the structural scaffolding that gives skin its firmness and resilience.

The result is a treatment that goes beyond surface-level improvement. Rejuran helps to genuinely rebuild the skin’s architecture, restoring hydration, thickness, elasticity, and barrier function from within.

Rejuran is particularly well suited for those experiencing the early to moderate signs of skin ageing, as well as those with thin, dehydrated, or environmentally damaged skin. At The Rejuvenation Space, we commonly use Rejuran to address fine lines and wrinkles across the face, loss of skin elasticity and firmness, rough or uneven skin texture, under-eye skin thinning and crepiness, compromised skin barrier function, and overall dullness or loss of radiance.

Rejuran is also beneficial for those looking to maintain and preserve their skin health proactively, supporting the skin’s structural integrity before more advanced signs of ageing develop.

The Rejuran product family includes formulations tailored to different areas and concerns. Rejuran Healer is the original formula, designed for overall facial rejuvenation and skin quality improvement. Rejuran I is specifically formulated for the delicate periorbital area, addressing fine lines, crepiness, and thinning skin around the eyes. Your clinician at The Rejuvenation Space will recommend the most appropriate formulation based on your individual needs and treatment goals.

A Rejuran treatment at The Rejuvenation Space typically takes 30 to 45 minutes. After cleansing the skin, a topical anaesthetic is applied for your comfort. The polynucleotide solution is then injected into the superficial dermis using a series of fine, precise microinjections across the treatment area.

You may notice small raised bumps at the injection sites immediately following the procedure, which typically flatten within 24 to 48 hours. Mild redness and swelling are common and usually resolve within a few days. Most clients begin to notice improvements in skin texture and hydration within the first two weeks, with continued improvement over the following months as collagen remodelling progresses.

For optimal results, we generally recommend an initial course of two to three treatments spaced three to four weeks apart, followed by maintenance sessions as advised by your clinician.

Rejuran aligns beautifully with our philosophy at The Rejuvenation Space. It is a treatment that honours your skin’s natural processes, working with your biology to stimulate real, meaningful change rather than relying on synthetic fillers or surface-level corrections. It is regenerative, evidence-informed, and designed to support your skin’s long-term health and vitality.

If you are seeking a treatment that goes deeper than the surface, that genuinely restores and revitalises your skin from within, Rejuran at The Rejuvenation Space may be the answer. Book your consultation today in Redfern, Sydney.