What Are Polynucleotides?

Polynucleotides (PN) are long chains of nucleotides, the building blocks of DNA and RNA. In the context of aesthetic medicine, polynucleotides derived from highly purified salmon DNA are used as a biostimulator, a treatment that stimulates the skin's own regenerative processes rather than simply filling or relaxing it.

Salmon DNA is used because its nucleotide sequence is highly compatible with human DNA, making it well-tolerated and effective. The polynucleotides are extensively purified to remove any proteins that could cause an immune response.

How Rejuran Works

When injected into the dermis, polynucleotides act as a scaffold and a signalling molecule. They stimulate fibroblast proliferation and activity, increasing the production of collagen, elastin, and hyaluronic acid. They also have anti-inflammatory properties and support the repair of UV-damaged DNA in skin cells.

Unlike hyaluronic acid fillers, which add volume by attracting water, Rejuran works by improving the intrinsic quality of the skin itself. The results are more subtle in the short term but more durable and natural-looking over time.

The treatment improves skin hydration, elasticity, texture, and density. Fine lines become less visible as the skin thickens and becomes more resilient. The overall effect is skin that looks healthier, more luminous, and more youthful, without looking altered.

What the Evidence Shows

Rejuran has a substantial body of clinical research behind it, particularly from South Korea where it has been in clinical use for over a decade. Studies have demonstrated improvements in skin elasticity, hydration, roughness, and wrinkle depth following a course of treatment.

Histological studies (examining skin tissue under a microscope) have shown measurable increases in dermal collagen density and fibroblast activity following Rejuran treatment, confirming that the improvements are structural, not just superficial.

Who Is Rejuran Suitable For?

Rejuran is suitable for a wide range of skin concerns and ages. It is particularly effective for clients with thinning skin, loss of density, fine lines, dehydration, and skin that has been damaged by sun exposure or environmental ageing.

It is also an excellent treatment for clients who want to improve their skin quality without the more dramatic changes associated with volume-adding treatments. The results are natural and progressive.

Rejuran can be used as a standalone treatment or in combination with skin needling, PRP, or other treatments for enhanced results.

What to Expect

Rejuran is administered via a series of small injections into the dermis. The treatment takes approximately 30 to 45 minutes. Some clients experience mild redness and small injection-site bumps immediately after treatment, which typically resolve within 24 to 48 hours.

Results build progressively over four to eight weeks as the skin responds to the treatment. A course of two to three sessions spaced four weeks apart is typically recommended for optimal results, followed by maintenance treatments every six to twelve months.